top of page




Bifidobacterium longum, BB536 4 Billion CFU
Bifidobacterium lactis, BB-12® 2 Billion CFU
Lactobacillus acidophilus, LA-5® 2 Billion CFU


Live Probiotics for
Total Gut and Immune Balance
Improve the gut-skin axis
Maintain intestinal health 1,2
Protect against infection 3,4
Prevent and relieve allergies 7
Improve bowel functions and relieve constipation 2
Enhance immune system 2,3,5
Reduce the risk of diarrhea 2,3,6
Reduce cholesterol levels 8
Support other health conditions (e.g. bone health) 2,3,9
Probiotics promote the growth of body’s natural microflora such as Bifidobacterium and Lactobacillus, and together they restore the balance of intestinal flora and maintain intestinal health. A healthy gut is the key to a healthy body. Having the right intestinal balance is important to enhance your overall health.
Bifidobacterium longum, BB536 is a patented strain from Morinaga Milk Industry Co. Ltd., Japan. Bifidobacterium lactis, BB-12® and Lactobacillus acidophilus, LA-5® are patented strains from Chr. Hansen A/S, Denmark.
References:
(1) Yaeshima T, Yakahashi S, Matsumoto N, Ishibashi N, Hayasawa H, Iino H (1997) Effect of yogurt containing Bifidobacterium longum BB536 on the intestinal environment, fecal characteristics and defecation frequency. Bioscience Microflora, 16(2):73-77. (2) Yuan Kun L, Seppo S (2008) Handbook of Probiotics and Prebiotics 2nd ed., Canada: A John Wiley & Sons, Inc., 441-443,480-485,488-491. (3) Guarner F, Khan AG, Garisch J et al. (2012) World gastroenterology organisation global guidelines: probiotics and prebiotics, October 2011. J Clin Gastroenterol, 46(6):468-481. (4) Namba K, Hatano M, Yaeshima T, Takase M, Suzuki K (2010) Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Bioscience, Biotechnology and Biochemistry, 74(5):939-945. (5) Rizzardini G, Eskesen D, Calder PC, Capetti A, Jespersen L, Clerici M (2011) Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model; a randomised, double-blind, placebo-controlled study. British Journal of Nutrition 107(6):876-884. (6) Bhalla A (2011) Randomized, placebo-controlled, double-blind, multicentric trial on efficacy and safety of Providac techsules (Lactobacillus acidophilus LA-5® and Bifidobacterium BB-12®) for prevention of Antibiotic-Associated Diarrhea in Indian patients. The Journal of Clinical Pharmacology, 51:1327 (7) Xiao JZ, Kondo S, Yanagisawa N, Takahashi N,Odamaki T, Iwabuchi N et al. (2006) Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clinical and Experimental Allergy, 36:1425-1435. (8) Kondo S, Shimizu K (2010) Approaches in the development of probiotics for improving metabolic disorders. Journal of Intestinal Microbiology, 24:281-286. (9) Igarashi M, Liyama Y, Kata R, Tomita M, Asami N, Ezawa I (1994) Effect of Bifidobacterium longum and lactulose on the strength of bone in ovariectomized osteoporosis model rats. Bifidus, 7:139-147. (10) Shioya M, Nakaoka K, Igarashi R, Iizuka N, Abe T, Benno Y (2000a) Effect of Fermented Milk Containing Bifidobacterium lactis FK 120 on the Fecal Flora, with Special Reference to Bifidobacterium Species, and Fecal Properties in Healthy Female Volunteers. Food Health and Nutrition Research, Journal of Nutritional Food, 3:7-18. (11) Shioya M, Nakaoka K, Iizuka N, Benno Y (2000b) Effect of Fermented Milk Containing Bifidobacterium lactis FK 120 on the Fecal Flora, with Special Reference to Bifidobacterium Species, and Fecal Properties in Healthy Volunteers. Food Health and Nutrition Research, Journal of Nutritional Food, 3:19-32.

Bifidobacterium longum, BB536, Bifidobacterium lactis, BB-12® and Lactobacillus acidophilus, LA-5® in PRO-BIOS have been demonstrated to exert many health benefits including gastrointestinal and immune system. The efficacy and safety of these 3 probiotic strains are well documented and are supported by more than 400 clinical studies to date, including human, animal and in-vitro studies.
The unique features of PRO-BIOS:
● Stomach and bile acid resistant
● Targeted delivery to the site of action
● Better survivability to reach the intestines
● Optimal stability of finished product


Bifidobacterium longum BB536
BB536 is a high survivable strain and has been recognized as a dominant microflora found naturally in the large intestine. It contributes to the human health by inhibiting the growth of harmful micro-organisms and hence protecting the body against various diseases.
The health benefits of BB536:
● Maintain intestinal health
● Protect against infection
● Relieve allergic conditions
● Reduce cholesterol levels
● Increase bone strength

Lactobacillus acidophilus LA-5®
LA-5® is able to survive the passage through the stomach and upper small intestine due to its tolerance against stomach and bile acid and also resistance to digestive enzymes. It is able to adhere to the intestinal mucosa and show good recovery of survivability in the intestines.
The health benefits of LA-5®:
● Improve the intestinal balance
● Relieve constipation
● Restore intestinal health
● Improve intestinal conditions
● Protect against diarrhea

Bifidobacterium lactis BB-12®
BB-12® shows high survival rate after consumption due to its high acid resistance and bile tolerance. An enzyme is present and active in BB-12® at all times and allows its quick response to high bile salt concentrations and thus facilitates the viable passage from the small intestine to the large intestine.
The health benefits of BB-12®:
● Improve bowel functions
● Reduce the risk of diarrhea
● Relieve digestive discomforts
● Inhibit pathogen
● Enhance immune system


bottom of page
).png)
.png)